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INTESTINAL INHIBITOR OF TRANSPLANTABLE TUMORS 665

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Comparison of the Effects of an Ornithine Decarboxylase Inhibitor on the Intestinal Epithelium and on Intestinal Tumor

growth of, the transplantable colon cancers. Because of the apparent selectivity of the antimitotic activity of DFMO towards tumors, ODC inhibitors may prove to be useful anticancer drugs ...

Induced stem cells - Wikiped

iPSc were first obtained in the form of transplantable teratocarcinoma induced by grafts taken from mouse embryos. Teratocarcinoma formed from somatic cells. ...

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER‐2/neu transgenic mice - Anisimov - 2002 .

Epitalon treatment reduced the cumulative number and the maximum size of tumors (p < 0.05). Furthermore, ... 10 It was also shown that the polypeptide pineal preparation Epithalamin® inhibits both the growth of transplantable mammary tumors and the ...

Comparison of the Effects of an Ornithine Decarboxylase Inhibitor on the Intestinal Epithelium and on Intestinal Tumo

DFMO was also found to suppress cell proliferation in, and the growth of, the transplantable colon cancers. Because of the apparent selectivity of the antimitotic activity of DFMO towards tumors, ODC inhibitors may prove to be useful anticancer drugs. ...

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cel

Following structure-activity analysis, the most potent inhibitor, an aminophenylthiazole (T16A inh-A01), had an IC 50 of ∼1 μ ... TMEM16A is also expressed in various tumors, where it has been proposed to play a role in tumor cell proliferation (4, 10). ...

Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumor

Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Tutton PJ, Barkla DH. Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in the synthesis of polyamines, it has a short half-life, and ...

Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the ra

The effects of cimetidine and indomethacin on the growth of dimethylhydrazine induced or transplanted intestinal tumours in the rat have been studied. Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis. Two models of rat intestinal

Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in ApcΔ716 mice involves stromal COX‐2 - Fujishita - 2015 .

Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc Δ716 mice involves stromal COX‐2 ... we and others reported earlier that the growth of intestinal tumors in Apc mutant mice required induction of COX‐2 in tumor stromal cells 3 ...

Further Studies on Effects of a Small Intestinal Microsomal Fraction Upon Transplantable Tumors. - Leslie R. Bennett, Frank E. Connon, Mary L .

The intestinal fraction markedly suppresses oxygen consumption of tumor slices, slightly reduces the respiration of normal lymphoid tissues, ...

Immunolocalization of a New Intestinal Antiproliferative Factor in Human Intestinal Epithelial Cells | SpringerLi

A new intestinal antiproliferative factor (IAF) with an approximate molecular weight of 120 kDa has been purified from the human small intestine. This factor blocks the progression ...

JCI Insight - CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blocka

developed mouse organoid-based transplantable models that have histologic and genetic similarity to human bladder cancer. ... IFN-γ ectopically expressed in the tumor microenvironment was sufficient to inhibit growth of tumors in which the epithelial Our ...

ERK activation drives intestinal tumorigenesis in Apc min/+ mice, Nature Medicine | 10.1038/nm.2143 | DeepDy

Read "ERK activation drives intestinal tumorigenesis in Apc min/+ mice, Nature Medicine" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors | NE

Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib.1 The use of these agents has improved ...

US20050022258A1 - Genetically determined mouse model of resistance to transplantable cancers - Google Paten

We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This ...

Contribution of host-derived growth factors to in vivo growth of a transplantable murine... - Europe PMC Article - Europe PubMed Centr

The contribution of host-derived growth factors to tumour growth in vivo was studied using the transplantable murine mammary carcinoma, MT1, grown in syngeneic mice. ...

JCI - IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcino

Mouse PDAC tumors treated with IDO1 inhibitor were utilized to further investigate the effects of IDO1 inhibition on MDSC function. ... slides in order to include the largest area of continuous neoplastic tissue while excluding normal pancreatic and intestinal The ...

Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or... - Europe PMC Article - Europe PubMed Centr

Abstract The effects of cimetidine and indomethacin on the growth of dimethylhydrazine induced or transplanted intestinal tumours in the rat have been studied. Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin ...

Frontiers | TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation | Immunolo

an inhibitor of murine TNF, because it is the only clinically available blocker that binds to ... Zvartsev RV, Qin Z, Nedospasov SA and Drutskaya MS (2016) TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC ...

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase | PN

Oncogenic Kit mutations are found in somatic gastrointestinal (GI) stromal tumors (GISTs) and mastocytosis. A mouse model for the study of constitutive activation of Kit in oncogenesis has been produced by a knock-in strategy introducing a Kit exon 11 ...

Multifaceted regulation and functions of YAP/TAZ in tumors (Revie

In particular, the crucial role of YAP/TAZ in tumors ensures their potential as targets in designing anticancer drugs. To date, ... promotes cytoplasmic retention and degradation of β-catenin via YAP/TAZ and the Hippo pathway serves as a tumor inhibitor in a novel ...

US Patent for Non-invasive approach for assessing tumors in living animals Patent (Patent # 6,926,890 issued August 9, 2005) - Justia Patents Sear

a secretable marker to an experimental animal and measuring secreted marker in the urine of animals bearing tumors formed by such recombinant tumor cells. Urinary marker levels are quantitatively related to tumor loads. Urinary marker can be ...