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Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis. - ACR Meeting Abstrac

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed ...

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces - Soft Matter (RSC Publishin

Lubricin and hyaluronic acid (HA), molecular constituents of synovial fluid, have long been theorized to play a role in joint lubrication and wear protection. While lubricin has been shown to function as a boundary lubricant, conflicting evidence exists as to the ...

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β. Here, we evaluate the role of cell surface ...

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β. Here, we evaluate the role of cell surface ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfac

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces ... a mixture the two to further understand the role of lubricin in boundary lubrication and to examine the hypotheses that lubri-cin and HA, alone or in ...

Lubricin is Required for the Structural Integrity and Post-natal Maintenance of TMJ - E. Koyama, C. Saunders, I. Salhab, R.S. Decker, I. Chen, H .

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci USA 110: 5852-5857. Google Scholar, Crossref, Medline Vol 93, Issue 7, 2014 ...

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

The biology of Lubricin: Near frictionless joint motion - ScienceDire

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Lubrication by biomacromolecules: mechanisms and biomimetic strategies - IOPscien

Waller K A, Zhang L X, Elsaid K A, Fleming B C, Warman M L and Jay G D 2013 Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl Acad. Sci. USA 110 5852–7 ...

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury .

Objective To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury ... Methods SF samples were obtained from both knees of 30 patients with unilateral ACL insufficiency, 32 ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Kimberly A Waller | Request P

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro | Scientific Repor

Waller, K. A. et al. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. PNAS USA 110, 5852–5857 (2013). CAS PubMed Article Google Scholar 16. Flannery, C. R. et al. Prevention of cartilage degeneration in a rat model of. 60 ...

NAVER Academic > Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosi

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L Warman, Gregory D Jay Publisher ...

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...