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US6183964B1 Method for identifying suppressor mutations

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US Patent for Method for identifying suppressor mutations for common p53 cancer mutations Patent (Patent # 6,183,964 issued February 6, 2001 .

Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in a similar fashion. In addition, the mutations themselves may be useful therapeutically ...

Method for identifying suppressor mutations for common p53 cancer mutations - The Johns Hopkins Universi

Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in ...

Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance ...- Oxford Academ

Fluorescence in situ hybridization (FISH) is a powerful technique used in the detection of chromosomal abnormalities. The high sensitivity and specif ...

A statistical method for identifying differential gene–gene co-expression patterns (pdf) | Paperi

A statistical method for identifying differential gene–gene co-expression patterns Bioinformatics, Nov 2004 Yinglei Lai, Baolin Wu, Liang Chen, Hongyu Zhao Yinglei Lai Baolin Wu Liang Chen Hongyu Zhao ...

Establishment of a PCR analysis method for canine BRCA2 - CO

In women, carriers of mutations in BRCA2, a tumor suppressor gene product, have a higher risk of breast cancer. Canine <it>BRCA2 </it>has also been suggested to have a relationship with mammary tumors. However, clearly deleterious BRCA2 mutations have ...

Method for identifying reading frame mutations - Apogene Biotechnologie GmbH & Co.

The invention relates to a simple and rapid method for identifying mutations in a gene of interest indicating an alteration in the reading frame of the proteins derived therefrom. The ...

Germline Mutations of the p53 Tumor-Suppressor Gene in Children and Young Adults with Second Malignant Neoplasms | NE

Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer. ...

Cancer Genome Analysis - Carnegie Mellon School of Computer Scien

Mutations in Tumor Suppressor Genes Mutations in Oncogenes Replication of DNA Damages Driver and Passenger Mutations • Driver’mutaons ...

Genetic screen - Wikiped

A genetic screen or mutagenesis screen is an experimental technique used to identify and select for individuals who possess a phenotype of interest in a mutagenized population. ...

Identifying suppressor mutations of ATR-X and ADNP syndromes using a novel CRISPR-based screening method in mice | Wellco

Identifying suppressor mutations of ATR-X and ADNP syndromes using a novel CRISPR-based screening method in mice Sir Henry Wellcome ...

SNP-Ratio Mapping (SRM): Identifying Lethal Alleles and Mutations in Complex Genetic Backgrounds by Next-Generation Sequencing | Geneti

The method is applicable to any model organism and mutagen causing mostly point mutations or small indels. SRM is the method of choice when working with (i) lethal mutations, (ii) hard-to-score phenotypes, (iii) mutations ...

THE ART AND DESIGN OF GENETIC SCREENS: CAENORHABDITIS ELEGA

The most straightforward method for identifying more genes that function in a given process is to screen for more mutants with the same phenotype. For example,John Sulston and H.Robert Horvitz 6 iden ...

Direct Selection for Transduction of Suppressor Mutations and Linkage of supD to fla Genes in... - Europe PMC Article - Europe P

FULL TEXT Abstract: A general method is presented for the direct selection of transductional clones of Salmonella containing suppressor mutations. ...

Evaluating the evaluation of cancer driver gen

Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a ... driver genes | cancer mutations | computational method evaluation T he search for genetic drivers of cancer has rapidly progressed ...

US20020068283A1 - Suppressor mutations for common P53 cancer mutations - Google Paten

Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in a similar fashion. In addition, the mutations themselves may be useful therapeutically ...

EP1472268A4 - Detection of a genetic predisposition to cancers and non-cancerous pathologies in mammals - Google Paten

EP1472268A4 EP03729659A EP03729659A EP1472268A4 EP 1472268 A4 EP1472268 A4 EP 1472268A4 EP 03729659 A EP03729659 A EP 03729659A EP 03729659 A EP03729659 A EP 03729659A EP 1472268 A4 EP1472268 A4 EP 1472268A4 Authority EP

Genetics Module 4 Flashcards | Quizl

newest method for identifying and analyzing the transcriptome Chromatin immunoprecipitation assays find proteins that bind to CREs chromatin immunoprecipitation (ChIP) can determine if proteins bind to a particular region of DNA stem cell

Technology - Method for Finding Mutations Caused by the Insertion of Repeated DN

This invention provides a novel method for identifying repeat insertion mutations, useful for identifying or classifying genetic diseases, and mapping complex traits controlled by repeat insertions. Value Proposition: Currently available human mutation detection ...

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets | Genome Medicine | Full Te

Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by ...

Procedure for Identifying Nonsense Mutatio

Abstract A method has been devised for the rapid identification of nonsense mutations (UAG, UAA, UGA codons) in Salmonella. The mutations to be tested are reverted, and the revertants are replica-printed onto lactose plates spread with lawns of tester strains.

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma D

We identified mutations throughout the tumor suppressor gene TP53 in circulating DNA from 46 ... However, identifying mutations across sizeable genomic regions spanning entire genes at an AF as low as 2%, or in few nanograms of fragmented template from ...